The effect of grape seed and green tea extracts on the pharmacokinetics of imatinib and its main metabolite, N-desmethyl imatinib, in rats

Abstract Background Imatinib is mainly metabolized by CYP3A4 and to a lesser extent by other isoenzymes, with N-desmethyl imatinib being its major equipotent metabolite. Being a CYP3A4 substrate, imatinib co-administration with CYP3A4 modulators would change its pharmacokinetic profile. The cancer c...

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Main Authors: Ruba S. Darweesh (Author), Tamam El-Elimat (Author), Aref Zayed (Author), Tareq N. Khamis (Author), Wahby M. Babaresh (Author), Tawfiq Arafat (Author), Ahmed H. Al Sharie (Author)
Format: Book
Published: BMC, 2020-11-01T00:00:00Z.
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