A novel method to estimate the absorption rate constant for two-compartment model fitted drugs without intravenous pharmacokinetic data

The in vivo performances of most drugs after extravascular administration are fitted well with the two-compartment pharmacokinetic (PK) model, but the estimation of absorption rate constant (ka) for these drugs becomes difficult during unavailability of intravenous PK data. Herein, we developed a no...

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Main Authors: Fan Liu (Author), Hanxi Yi (Author), Lei Wang (Author), Zeneng Cheng (Author), Guoqing Zhang (Author)
Format: Book
Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
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