Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein

• Main Authors: Tingting Wang (Author), Yingjie Guo (Author), Yang He (Author), Tianming Ren (Author), Lei Yin (Author), John Paul Fawcett (Author), Jingkai Gu (Author), Huimin Sun (Author)
• Format: Book
• Published: Elsevier, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polyethylene glycols (PEGs) in general use are polydisperse molecules with molecular weight (MW) distributed around an average value applied in their designation e.g., PEG 4000. Previous research has shown that PEGs can act as P-glycoprotein (P-gp) inhibitors with the potential to affect the absorpt...