Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis

• Main Authors: Savina Apolloni (Author), Susanna Amadio (Author), Chiara Parisi (Author), Alessandra Matteucci (Author), Rosa L. Potenza (Author), Monica Armida (Author), Patrizia Popoli (Author), Nadia D'Ambrosi (Author), Cinzia Volonté (Author)
• Format: Book
• Published: The Company of Biologists, 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years there has been an increasing awareness of the role of P2X7, a receptor for extracellular ATP, in modulating physiopathological mechanisms in the central nervous system. In particular, P2X7 has been shown to be implicated in neuropsychiatry, chronic pain, neurodegeneration and neuroin...