Characteristics and thermodynamics of the interaction of 6-shogaol with human serum albumin as studied by isothermal titration calorimetry

• Principais autores: Shevin Rizal Feroz (Autor), Sri Nurestri Abdul Malek (Autor), Saad Tayyab (Autor)
• Formato: Livro
• Publicado em: Universidade de São Paulo.
• Assuntos: article
• Acesso em linha: Connect to this object online.

ABSTRACT The interaction between 6-shogaol, a pharmacologically active ginger constituent, and human serum albumin (HSA), the main in vivo drug transporter, was investigated using isothermal titration calorimetry (ITC). The value of the binding constant, Ka (5.02 ± 1.37 × 104 M−1) obtained for the 6...