Non-covalent cyclic peptides simultaneously targeting Mpro and NRP1 are highly effective against Omicron BA.2.75

• Main Authors: Shengnan Yin (Author), Shuang Mei (Author), Zhiqin Li (Author), Zhen Xu (Author), Yuting Wu (Author), Xiujuan Chen (Author), Dongmei Liu (Author), Miao-Miao Niu (Author), Jindong Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Available vaccine-based immunity may at high risk of being evaded due to substantial mutations in the variant Omicron. The main protease (Mpro) of SARS-CoV-2 and human neuropilin-1 (NRP1), two less mutable proteins, have been reported to be crucial for SARS-CoV-2 replication and entry into host cell...