A mouse model of hypoplastic left heart syndrome demonstrating left heart hypoplasia and retrograde aortic arch flow

• Main Authors: Anum Rahman (Author), Taylor DeYoung (Author), Lindsay S. Cahill (Author), Yohan Yee (Author), Sarah K. Debebe (Author), Owen Botelho (Author), Mike Seed (Author), Rajiv R. Chaturvedi (Author), John G. Sled (Author)
• Format: Book
• Published: The Company of Biologists, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In hypoplastic left heart syndrome (HLHS), the mechanisms leading to left heart hypoplasia and their associated fetal abnormalities are largely unknown. Current animal models have limited utility in resolving these questions as they either do not fully reproduce the cardiac phenotype, do not survive...