Synthesis, in silico prediction of sites of metabolism and in-vitro hepatotoxicity evaluationofnew seriesN'-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides

• Main Authors: Javor Mitkov (Author), Magdalena Kondeva-Burdina (Author), Maya Georgieva (Author), Alexander Zlatkov (Author)
• Formato: Livro
• Publicado em: Pensoft Publishers, 2022-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

New series of 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazide derivatives were designed and synthesized. The targed compounds were obtained in yields of 54 to 100% and their structures were elucidated by FTIR,1H NMR,13C NMR, MS and microanalyses. The tested compounds were subjected to in silico...