Synthesis and biological evaluation of thiazolidinedione derivatives with high ligand efficiency to P. aeruginosa PhzS

• Main Authors: Thamires Quadros Froes (Author), Bianca Trindade Chaves (Author), Marina Sena Mendes (Author), Rafael Matos Ximenes (Author), Ivanildo Mangueira da Silva (Author), Priscila Brandão Gomes da Silva (Author), Julianna Ferreira Cavalcanti de Albuquerque (Author), Marcelo Santos Castilho (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The thiazolidinone ring is found in compounds that have widespan biology activity and there is mechanism-based evidence that compounds bearing this moiety inhibit P. aeruginosa PhzS (PaPzhS), a key enzyme in the biosynthesis of the virulence factor named pyocyanin. Ten novel thiazolidinone derivativ...