CYP2D7 sequence variation interferes with TaqMan CYP2D6*15 and *35 genotyping

• मुख्य लेखकों: Amanda K Riffel (लेखक), Mehdi eDehghani (लेखक), Toinette eHartshorne (लेखक), Kristen eFloyd (लेखक), J Steven eLeeder (लेखक), Kevin P Rosenblatt (लेखक), Andrea eGaedigk (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2016-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the presence of two pseudogenes, CYP2D7 and CYP2D8, structural and copy number variation and numerous single nucleotide polymorphisms (SNP...