Effects of general and central adiposity on circulating lipoprotein, lipid, and metabolite levels in UK Biobank: A multivariable Mendelian randomization study

• Main Authors: Joshua A. Bell (Author), Tom G. Richardson (Author), Qin Wang (Author), Eleanor Sanderson (Author), Tom Palmer (Author), Venexia Walker (Author), Linda M. O'Keeffe (Author), Nicholas J. Timpson (Author), Anna Cichonska (Author), Heli Julkunen (Author), Peter Würtz (Author), Michael V. Holmes (Author), George Davey Smith (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Background: The direct effects of general adiposity (body mass index (BMI)) and central adiposity (waist-to-hip-ratio (WHR)) on circulating lipoproteins, lipids, and metabolites are unknown. Methods: We used new metabolic data from UK Biobank (N=109,532, a five-fold higher N over previous s...