Engineering highly efficient backsplicing and translation of synthetic circRNAs

Engineering highly efficient backsplicing and translation of synthetic circRNAs

Circular RNAs (circRNAs) are highly stable RNA molecules that are attractive templates for expression of therapeutic proteins and non-coding RNAs. In eukaryotes, circRNAs are primarily generated by the spliceosome through backsplicing. Here, we interrogate different molecular elements including intr...

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Main Authors: Rita M. Meganck (Author), Jiacheng Liu (Author), Andrew E. Hale (Author), Katherine E. Simon (Author), Marco M. Fanous (Author), Heather A. Vincent (Author), Jeremy E. Wilusz (Author), Nathaniel J. Moorman (Author), William F. Marzluff (Author), Aravind Asokan (Author)
Format: Book
Published: Elsevier, 2021-03-01T00:00:00Z.
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