Discovery of a Novel MyD88 Inhibitor M20 and Its Protection Against Sepsis-Mediated Acute Lung Injury

• Main Authors: Jiali Song (Author), Daoxing Chen (Author), Yingqiao Pan (Author), Xueqin Shi (Author), Qian Liu (Author), Xiaoyao Lu (Author), Ximing Xu (Author), Gaozhi Chen (Author), Yuepiao Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myeloid differentiation factor 88 (MyD88) is a hub protein in the Toll-like receptor signaling pathway, which acts as a master switch for numerous inflammatory diseases, including acute lung injury (ALI). Although this protein is considered as a crucial therapeutic target, there are currently no cli...