An Efficient UPLC-MS/MS Method Established to Detect Relugolix Concentration in Rat Plasma

• Главные авторы: Liying Xing (Автор), Ya-nan Liu (Автор), Hongye Yao (Автор), Tingting Wang (Автор), Fuchen Xie (Автор), Shunbin Luo (Автор), Pingping Luo (Автор), Shengling Tang (Автор)
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• Опубликовано: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Предметы: article
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Relugolix, a gonadotropin-releasing hormone (GnRH) receptor antagonist, has been well studied in the treatment of endometriosis symptomatic. It is mainly metabolized by the CYP3A subfamily of P450 enzymes, while minorly metabolized by CYP2C8. Daidzein in different dose groups exhibited a certain ind...