An Efficient UPLC-MS/MS Method Established to Detect Relugolix Concentration in Rat Plasma

• Hoofdauteurs: Liying Xing (Auteur), Ya-nan Liu (Auteur), Hongye Yao (Auteur), Tingting Wang (Auteur), Fuchen Xie (Auteur), Shunbin Luo (Auteur), Pingping Luo (Auteur), Shengling Tang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Relugolix, a gonadotropin-releasing hormone (GnRH) receptor antagonist, has been well studied in the treatment of endometriosis symptomatic. It is mainly metabolized by the CYP3A subfamily of P450 enzymes, while minorly metabolized by CYP2C8. Daidzein in different dose groups exhibited a certain ind...