Microinjection of Orexin-A into the Locus Coeruleus Area Induces Morphine Withdrawal Behaviors in Morphine Independent Rats
Introduction: Orexin neuropeptide has a role in opioid withdrawal behaviors. Orexin-expressing neurons that are present in the hypothalamic nuclei send dense projections to the Locus Coeruleus (LC). Withdrawal syndrome is temporally associated with hyperactivity of LC neurons. LC neurons do not show...
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Drug Control Headquarters, Research and Education Office,
2012-02-01T00:00:00Z.
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