An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation

• Main Authors: Eduarde Rohner (Author), Nevin Witman (Author), Jesper Sohlmer (Author), Erwin De Genst (Author), William E. Louch (Author), Makoto Sahara (Author), Kenneth R. Chien (Author)
• Format: Book
• Published: BMC, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be clarified. Previous studies have shown the implication between an impair...