Synthesis, Biological Evaluation and Machine Learning Prediction Model for Fluorinated <i>Cinchona</i> Alkaloid-Based Derivatives as Cholinesterase Inhibitors

• Principais autores: Alma Ramić (Autor), Ana Matošević (Autor), Barbara Debanić (Autor), Ana Mikelić (Autor), Ines Primožič (Autor), Anita Bosak (Autor), Tomica Hrenar (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

A series of 46 <i>Cinchona</i> alkaloid derivatives that differ in positions of fluorine atom(s) in the molecule were synthesized and tested as human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. All tested compounds reversibly inhibited AChE and BChE in the na...