Formulation of SARS-CoV-2 Spike Protein with CpG Oligodeoxynucleotides and Squalene Nanoparticles Modulates Immunological Aspects Following Intranasal Delivery

• Auteurs principaux: Hui-Min Ho (Auteur), Chiung-Yi Huang (Auteur), Chung-Hsiang Yang (Auteur), Shih-Jen Liu (Auteur), Hsin-Wei Chen (Auteur), Guann-Yi Yu (Auteur), Jen-Kun Chen (Auteur), Tsung-Hsien Chuang (Auteur), Ming-Hsi Huang (Auteur)
• Format: Livre
• Publié: MDPI AG, 2022-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Nasal spray vaccination is viewed as a promising strategy for inducing both mucosal and systemic protection against respiratory SARS-CoV-2 coronavirus. Toward this goal, a safe and efficacious mucosal adjuvant is necessary for the transportation of the antigen across the mucosal membrane and antigen...