Formulation of SARS-CoV-2 Spike Protein with CpG Oligodeoxynucleotides and Squalene Nanoparticles Modulates Immunological Aspects Following Intranasal Delivery

• Main Authors: Hui-Min Ho (Author), Chiung-Yi Huang (Author), Chung-Hsiang Yang (Author), Shih-Jen Liu (Author), Hsin-Wei Chen (Author), Guann-Yi Yu (Author), Jen-Kun Chen (Author), Tsung-Hsien Chuang (Author), Ming-Hsi Huang (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nasal spray vaccination is viewed as a promising strategy for inducing both mucosal and systemic protection against respiratory SARS-CoV-2 coronavirus. Toward this goal, a safe and efficacious mucosal adjuvant is necessary for the transportation of the antigen across the mucosal membrane and antigen...