CDR1as regulates α-synuclein-mediated ischemic brain damage by controlling miR-7 availability

• Main Authors: Suresh L. Mehta (Author), Anil K. Chokkalla (Author), Saivenkateshkomal Bathula (Author), Vijay Arruri (Author), Bharath Chelluboina (Author), Raghu Vemuganti (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transient focal ischemia decreased microRNA-7 (miR-7) levels, leading to derepression of its major target α-synuclein (α-Syn) that promotes secondary brain damage. Circular RNA CDR1as is known to regulate miR-7 abundance and function. Hence, we currently evaluated its functional significance after f...