Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers

• Main Authors: Daniel M Spagnolo (Author), Rekha Gyanchandani (Author), Yousef Al-Kofahi (Author), Andrew M Stern (Author), Timothy R Lezon (Author), Albert Gough (Author), Dan E Meyer (Author), Fiona Ginty (Author), Brion Sarachan (Author), Jeffrey Fine (Author), Adrian V Lee (Author), D Lansing Taylor (Author), S Chakra Chennubhotla (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Measures of spatial intratumor heterogeneity are potentially important diagnostic biomarkers for cancer progression, proliferation, and response to therapy. Spatial relationships among cells including cancer and stromal cells in the tumor microenvironment (TME) are key contributors to he...