Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

• Main Authors: Kathryn P. Burdon (Author), Megan E. Rudock (Author), Allison B. Lehtinen (Author), Carl D. Langefeld (Author), Donald W. Bowden (Author), Thomas C. Register (Author), Yongmei Liu (Author), Barry I. Freedman (Author), J. Jeffrey Carr (Author), Catherine C. Hedrick (Author), Stephen S. Rich (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims. Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds. Methods. Families with two or more siblings with type 2 di...