Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway

• Main Authors: Jing Sun (Author), Wugui Chen (Author), Songtao Li (Author), Sizhen Yang (Author), Ying Zhang (Author), Xu Hu (Author), Hao Qiu (Author), Jigong Wu (Author), Shangcheng Xu (Author), Tongwei Chu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms remain unclear. Via conducting a series of biochemical experiments with in vitro cell lines, this study investigated the role and mecha...