Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production

• Main Authors: Rui Zhang (Author), Baoshan Liu (Author), Xinhui Fan (Author), Wenjun Wang (Author), Tonghui Xu (Author), Shujian Wei (Author), Wen Zheng (Author), Qiuhuan Yuan (Author), Luyao Gao (Author), Xinxin Yin (Author), Boyuan Zheng (Author), Chuanxin Zhang (Author), Shuai Zhang (Author), Kehui Yang (Author), Mengyang Xue (Author), Shuo Wang (Author), Feng Xu (Author), Jiali Wang (Author), Yihai Cao (Author), Yuguo Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Post-cardiac arrest myocardial dysfunction significantly contributes to early mortality after the return of spontaneous circulation. However, no effective therapy is available now. Aldehyde dehydrogenase 2 (ALDH2) enzyme has been shown to protect the heart from aldehyde toxicity such as 4-hydroxy-2-...