AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice

• Main Authors: Cristina Mallol (Author), Estefania Casana (Author), Veronica Jimenez (Author), Alba Casellas (Author), Virginia Haurigot (Author), Claudia Jambrina (Author), Victor Sacristan (Author), Meritxell Morró (Author), Judith Agudo (Author), Laia Vilà (Author), Fatima Bosch (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Type 1 diabetes is characterized by autoimmune destruction of β-cells leading to severe insulin deficiency. Although many improvements have been made in recent years, exogenous insulin therapy is still imperfect; new therapeutic approaches, focusing on preserving/expanding β-cell mass and...