Selective depletion of radiolabeled HER2-specific antibody for contrast improvement during PET

• Main Authors: Priyanka Khare (Author), Wei Sun (Author), Sreevidhya Ramakrishnan (Author), Rafal Swiercz (Author), Guiyang Hao (Author), Su-Tang Lo (Author), Kien Nham (Author), Xiankai Sun (Author), Raimund J. Ober (Author), E. Sally Ward (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prolonged in vivo persistence of antibodies results in high background and poor contrast during their use as molecular imaging agents for positron emission tomography (PET). We have recently described a class of engineered Fc fusion proteins that selectively deplete antigen-specific antibodies w...