Ginkgo biloba Extract and Ginkgolide Antiarrhythmic Potential by Targeting hERG and ICa-L Channel

• Main Authors: Xin Zhao (Author), Hong Yao (Author), Hao-Lan Yin (Author), Qi-Lei Zhu (Author), Jia-Liang Sun (Author), Wei Ma (Author), Yuan-Qi Shi (Author), Zhao-Guang Liang (Author), Bao-Xin Li (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of Ginkgo biloba extract (GBE) and ginkgolide (GLD) on human ether-a-go-go-related gene (hERG)-encoded K+ channels and its underlying mechanisms in the hERG-HEK293 cell line by determining GBE- and GLD-induced changes in action potential duration (APD), L-type calcium cur...