Altered Protein Expression of Cardiac CYP2J and Hepatic CYP2C, CYP4A, and CYP4F in a Mouse Model of Type II Diabetes-A Link in the Onset and Development of Cardiovascular Disease?

• Main Authors: Benoit Drolet (Author), Sylvie Pilote (Author), Carolanne Gélinas (Author), Alida-Douce Kamaliza (Author), Audrey Blais-Boilard (Author), Jessica Virgili (Author), Dany Patoine (Author), Chantale Simard (Author)
• Format: Book
• Published: MDPI AG, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Arachidonic acid can be metabolized by cytochrome P450 (CYP450) enzymes in a tissue- and cell-specific manner to generate vasoactive products such as epoxyeicosatrienoic acids (EETs-cardioprotective) and hydroxyeicosatetraenoic acids (HETEs-cardiotoxic). Type II diabetes is a well-recognized risk fa...