Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer's disease

• Auteurs principaux: Subramaniyan Vijayakumar (Auteur), Palani Manogar (Auteur), Srinivasan Prabhu (Auteur), Ram Avadhar Sanjeevkumar Singh (Auteur)
• Format: Livre
• Publié: Elsevier, 2018-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Acetylcholinesterase (AChE) plays an important role in Alzheimer's disease (AD). The excessive activity of AChE causes various neuronal problems, particularly dementia and neuronal cell deaths. Generally, anti-AChE drugs induce some serious neuronal side effects in humans. Therefore, this study...