Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection.

• Main Authors: Iris J Gonzalez-Leal (Author), Bianca Röger (Author), Angela Schwarz (Author), Tanja Schirmeister (Author), Thomas Reinheckel (Author), Manfred B Lutz (Author), Heidrun Moll (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Resistance and susceptibility to Leishmania major infection in the murine model is determined by the capacity of the host to mount either a protective Th1 response or a Th2 response associated with disease progression. Previous reports involving the use of cysteine cathepsin inhibitors indicated tha...