Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin

• Main Authors: Esteban A. Orellana (Author), Ahmed M. Abdelaal (Author), Loganathan Rangasamy (Author), Srinivasarao Tenneti (Author), Sunghyun Myoung (Author), Philip S. Low (Author), Andrea L. Kasinski (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The therapeutic promise of small-RNA therapeutics is limited, not only by the lack of delivery vehicles, but also by the inability of the small RNAs to reach intracellular compartments where they can be biologically active. We previously reported successful delivery of functionally active miRNAs via...