Nitric Oxide Inhibits Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase Expression and Its Own Production Through the cGMP Signaling Pathway in Murine Microglia BV-2 Cells

• 主要な著者: Yasuhiro Yoshioka (著者), Nobuo Takeda (著者), Akiko Yamamuro (著者), Atsushi Kasai (著者), Sadaaki Maeda (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2010-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The present study examined the effect of the nitric oxide (NO) donor NOC18 on lipopolysaccharide (LPS)-induced NO production to investigate a regulation mechanism of NO production by microglial cells. LPS increased the levels of NO and inducible NO synthase (iNOS) protein in BV-2 murine microglial c...