Nitric Oxide Inhibits Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase Expression and Its Own Production Through the cGMP Signaling Pathway in Murine Microglia BV-2 Cells

• Autori principali: Yasuhiro Yoshioka (Autore), Nobuo Takeda (Autore), Akiko Yamamuro (Autore), Atsushi Kasai (Autore), Sadaaki Maeda (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2010-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The present study examined the effect of the nitric oxide (NO) donor NOC18 on lipopolysaccharide (LPS)-induced NO production to investigate a regulation mechanism of NO production by microglial cells. LPS increased the levels of NO and inducible NO synthase (iNOS) protein in BV-2 murine microglial c...