Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2

• Main Authors: Hong-can Ren (Author), Jian-guo Sun (Author), Ji-ye A (Author), Sheng-hua Gu (Author), Jian Shi (Author), Feng Shao (Author), Hua Ai (Author), Jing-wei Zhang (Author), Ying Peng (Author), Bei Yan (Author), Qing Huang (Author), Lin-sheng Liu (Author), Yang Sai (Author), Guang-ji Wang (Author), Cheng-guang Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: The 20(S)-ginsenoside Rh2 (Rh2) is being developed as a new antitumor drug. However, to date, little is known about the kinetics of its deglycosylation metabolite (protopanoxadiol) (PPD) following Rh2 administration. The aim of this work was to 1) simultaneously characterise the pharmacokinetic...