Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition

• Main Authors: Yunzhao Xiong (Author), Yi Chang (Author), Juan Hao (Author), Cuijuan Zhang (Author), Fan Yang (Author), Zheng Wang (Author), Yunmeng Liu (Author), Xiangting Wang (Author), Shengyu Mu (Author), Qingyou Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Severe renal fibrosis often occurs in obstructive kidney disease, not only in the obstructed kidney but also in the contralateral kidney, causing renal dysfunction. Although the mechanisms of injury in obstructed kidney have been studied for years, the pathogenesis of fibrosis in the contralateral k...