Nicorandil prevents sirolimus-induced production of reactive oxygen species, endothelial dysfunction, and thrombus formation

• Main Authors: Ken Aizawa (Author), Youko Takahari (Author), Naoko Higashijima (Author), Kenichi Serizawa (Author), Kenji Yogo (Author), Nobuhiko Ishizuka (Author), Koichi Endo (Author), Naoto Fukuyama (Author), Katsuya Hirano (Author), Hideyuki Ishida (Author)
• Format: Book
• Published: Elsevier, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirolimus (SRL) is widely used to prevent restenosis after percutaneous coronary intervention. However, its beneficial effect is hampered by complications of thrombosis. Several studies imply that reactive oxygen species (ROS) play a critical role in endothelial dysfunction and thrombus formation. T...