Design, Synthesis, and Antidepressant Activity Study of Novel Aryl Piperazines Targeting Both 5-HT1A and Sigma-1 Receptors

Abstract A total of 20 novel aryl piperazine derivatives were designed and synthesized, and their structures were confirmed by mass spectrometry and nuclear magnetic resonance analyses. Their 5-HT1A and sigma-1 receptor affinities were determined, and six of them showed high affinities (K i < 20...

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Main Authors: Yan-Na Ni (Author), Xin-Li Du (Author), Tao Wang (Author), Yuan-Yuan Chen (Author), Xiang-Qing Xu (Author), Song Zhao (Author), Jian-Qi Li (Author), Guan Wang (Author)
Format: Book
Published: Georg Thieme Verlag KG, 2021-12-01T00:00:00Z.
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3rd Floor Main Library

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