Design, Synthesis, and Antidepressant Activity Study of Novel Aryl Piperazines Targeting Both 5-HT1A and Sigma-1 Receptors

• Auteurs principaux: Yan-Na Ni (Auteur), Xin-Li Du (Auteur), Tao Wang (Auteur), Yuan-Yuan Chen (Auteur), Xiang-Qing Xu (Auteur), Song Zhao (Auteur), Jian-Qi Li (Auteur), Guan Wang (Auteur)
• Format: Livre
• Publié: Georg Thieme Verlag KG, 2021-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract A total of 20 novel aryl piperazine derivatives were designed and synthesized, and their structures were confirmed by mass spectrometry and nuclear magnetic resonance analyses. Their 5-HT1A and sigma-1 receptor affinities were determined, and six of them showed high affinities (K i < 20...