Plumbagin induces RPE cell cycle arrest and apoptosis via p38 MARK and PI3K/AKT/mTOR signaling pathways in PVR

Abstract Background This study aimed to explore the effects of plumbagin (PLB) on ARPE-19 cells and underlying mechanism. Methods Cultured ARPE-19 cells were treated with various concentrations (0, 5, 15, and 25 μM) of PLB for 24 h or with 15 μM PLB for 12, 24 and 48 h. Then cell viability was evalu...

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Main Authors: Haiting Chen (Author), Huifang Wang (Author), Jianbin An (Author), Qingli Shang (Author), Jingxue Ma (Author)
Format: Book
Published: BMC, 2018-03-01T00:00:00Z.
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3rd Floor Main Library

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