Stage-specific adhesion of Leishmania promastigotes to sand fly midguts assessed using an improved comparative binding assay.

• Main Authors: Raymond Wilson (Author), Michelle D Bates (Author), Anna Dostalova (Author), Lucie Jecna (Author), Rod J Dillon (Author), Petr Volf (Author), Paul A Bates (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The binding of Leishmania promastigotes to the midgut epithelium is regarded as an essential part of the life-cycle in the sand fly vector, enabling the parasites to persist beyond the initial blood meal phase and establish the infection. However, the precise nature of the promastigote stage(s) that...