The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3

• Main Authors: Yating Cheng (Author), Yan Yang (Author), Yinan Wu (Author), Wencheng Wang (Author), Lichun Xiao (Author), Yifan Zhang (Author), Jianzhong Tang (Author), Ya-Dong Huang (Author), Shu Zhang (Author), Qi Xiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) enzyme is a potential therapeutic target for hormone-dependent prostate cancer, as it is the key enzyme in the last step of testosterone (T) biosynthesis. A curcumin analog, H10, was optimized for inhibiting T production in LC540 cells that stab...