Relaxin-encapsulated polymeric metformin nanoparticles remodel tumor immune microenvironment by reducing CAFs for efficient triple-negative breast cancer immunotherapy

• Main Authors: Hongyan Zhang (Author), Liying Chen (Author), Yue Zhao (Author), Ningchao Luo (Author), Jingbin Shi (Author), Shujun Xu (Author), Lisha Ma (Author), Menglin Wang (Author), Mancang Gu (Author), Chaofeng Mu (Author), Yang Xiong (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer-associated fibroblasts (CAFs) are one of the most abundant stromal cells in the tumor microenvironment which mediate desmoplastic response and are the primary driver for an immunosuppressive microenvironment, leading to the failure of triple-negative breast cancer (TNBC) immunotherapy. Theref...