BRAF mutation in hairy cell leukemia

• Main Authors: Ahmad Ahmadzadeh (Author), Saeid Shahrabi (Author), Kaveh Jaseb (Author), Fatemeh Norozi (Author), Mohammad Shahjahani (Author), Tina Vosoughi (Author), Saeideh Hajizamani (Author), Najmaldin Saki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BRAF is a serine/threonine kinase with a regulatory role in the mitogen-activated protein kinase (MAPK) signaling pathway. A mutation in the RAF gene, especially in BRAF protein, leads to an increased stimulation of this cascade, causing uncontrolled cell division and development of malignancy. Seve...