Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions

• Main Authors: Michael Mullin (Author), James McClory (Author), Winston Haynes (Author), Justin Grace (Author), Nathan Robertson (Author), Gino van Heeke (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThe development of bispecific antibodies that bind at least two different targets relies on bringing together multiple binding domains with different binding properties and biophysical characteristics to produce a drug-like therapeutic. These building blocks play an important role in the ove...