Sorangicin A Is Active against <i>Chlamydia</i> in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment

Sorangicin A Is Active against <i>Chlamydia</i> in Cell Culture, Explanted Fallopian Tubes, and Topical In Vivo Treatment

Current treatment of <i>Chlamydia trachomatis</i> using doxycycline and azithromycin introduces detrimental side effects on the host's microbiota. As a potential alternative treatment, the myxobacterial natural product sorangicin A (SorA) blocks the bacterial RNA polymerase. In this...

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Main Authors: Simon Graspeuntner (Author), Katharina Koethke (Author), Celeste Scholz (Author), Lea Semmler (Author), Mariia Lupatsii (Author), Laura Kirchhoff (Author), Jennifer Herrmann (Author), Katharina Rox (Author), Kathrin Wittstein (Author), Nadja Käding (Author), Lars C. Hanker (Author), Marc Stadler (Author), Mark Brönstrup (Author), Rolf Müller (Author), Kensuke Shima (Author), Jan Rupp (Author)
Format: Book
Published: MDPI AG, 2023-04-01T00:00:00Z.
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