ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK

• Main Authors: Peiran Song (Author), Gang Bai (Author), Shingpan Chan (Author), Tao Zhang (Author), Linjiang Tong (Author), Yi Su (Author), Yanyan Shen (Author), Yi Chen (Author), Yingqiang Liu (Author), Mengzhen Lai (Author), Yi Ning (Author), Haotian Tang (Author), Yan Fang (Author), Ke Ding (Author), Jian Ding (Author), Hua Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperactivation of Bruton's tyrosine kinase (BTK) or interleukin-2-inducible T cell kinase (ITK) has been attributed to the pathogenesis of B-cell lymphoma or T-cell leukemia, respectively, which suggests that Bruton's tyrosine kinase and interleukin-2-inducible T cell kinase are critical...