Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose

• Hauptverfasser: Joshua Bloom (VerfasserIn), Georgios Pantouris (VerfasserIn), Mingzhu He (VerfasserIn), Bayan Aljabari (VerfasserIn), Lopa Mishra (VerfasserIn), Ramu Manjula (VerfasserIn), Andrew Parkins (VerfasserIn), Elias J. Lolis (VerfasserIn), Yousef Al-Abed (VerfasserIn)
• Format: Buch
• Veröffentlicht: BMC, 2024-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Background Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and non-inflammatory diseases, including liver injury induced by acetaminophen (APAP) overdose. Multiple small molecule inhibitors of MIF have been described,...