Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose

• Main Authors: Joshua Bloom (Author), Georgios Pantouris (Author), Mingzhu He (Author), Bayan Aljabari (Author), Lopa Mishra (Author), Ramu Manjula (Author), Andrew Parkins (Author), Elias J. Lolis (Author), Yousef Al-Abed (Author)
• Format: Book
• Published: BMC, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and non-inflammatory diseases, including liver injury induced by acetaminophen (APAP) overdose. Multiple small molecule inhibitors of MIF have been described,...