Ajugol's upregulation of TFEB-mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model

• Main Authors: Jingtao Wu (Author), Heng Yu (Author), Yangcan Jin (Author), Jingquan Wang (Author), Liwen Zhou (Author), Teng Cheng (Author), Zhao Zhang (Author), Binghao Lin (Author), Jiansen Miao (Author), Zhongke Lin (Author)
• Format: Book
• Published: BMC, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Osteoarthritis (OA), a degenerative disease with a high global prevalence, is characterized by the degradation of the extracellular matrix (ECM) and the apoptosis of chondrocytes. Ajugol, a extract derived from the herb Rehmannia glutinosa, has not yet been investigated for its p...