Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids

• Main Authors: Andrea Bacci (Author), Francesca Corsi (Author), Massimiliano Runfola (Author), Simona Sestito (Author), Ilaria Piano (Author), Clementina Manera (Author), Giuseppe Saccomanni (Author), Claudia Gargini (Author), Simona Rapposelli (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overproduction of reactive oxygen species (ROS) and alterations in metallostasis are common and related hallmarks in several neurodegenerative diseases (NDDs). Nature-based derivatives always represent an attractive tool in MTDL drug design, especially against ROS in NDDs. On this notion, we designe...