A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling

A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling

In this study, we examined the effect of the GP130-targeting molecule, LMT-28, on lipopolysaccharide- (LPS-) induced bone resorption around implants in diabetic models using in vitro and rat animal experiments. First, LMT-28 was added to osteoblasts stimulated by LPS and advanced glycation end produ...

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Main Authors: Qi-qi Liu (Author), Wei-wei Wu (Author), Jian Yang (Author), Rui-bin Wang (Author), Ling-ling Yuan (Author), Pei-zhao Peng (Author), Mao-yun Zeng (Author), Ke Yu (Author)
Format: Book
Published: Hindawi Limited, 2023-01-01T00:00:00Z.
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