Exploring the medicinal potential of Dark Chemical Matters (DCM) to design promising inhibitors for PLpro of SARS-CoV-2 using molecular screening and simulation approaches

• Main Authors: Abbas Khan (Author), Ayesha Liaqat (Author), Adan Masood (Author), Syed Shujait Ali (Author), Liaqat Ali (Author), Abdulrahman Alshammari (Author), Abdullah F. Alasmari (Author), Anwar Mohammad (Author), Yasir Waheed (Author), Dong-Qing Wei (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The growing concerns and cases of COVID-19 with the appearance of novel variants i.e., BA.2.75. BA.5 and XBB have prompted demand for more effective treatment options that could overcome the risk of immune evasion. For this purpose, discovering novel small molecules to inhibit druggable proteins suc...