Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes

• Main Authors: Rojanasakul Yon (Author), Yun Chawon (Author), Kramer Sara J (Author), Dorfleutner Andrea (Author), Bryan Nicole B (Author), Stehlik Christian (Author)
• Format: Book
• Published: BMC, 2010-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The apoptotic speck-like protein containing a caspase recruitment domain (ASC) is the essential adaptor protein for caspase 1 mediated interleukin (IL)-1β and IL-18 processing in inflammasomes. It bridges activated Nod like receptors...