Inactivating mutations in genes encoding for components of the BAF/PBAF complex and immune-checkpoint inhibitor outcome

• मुख्य लेखकों: Kevin Courtet (लेखक), Yec'han Laizet (लेखक), Carlo Lucchesi (लेखक), Alban Bessede (लेखक), Antoine Italiano (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Alterations of genes encoding subunits of the BAF/PBAF complexes are among the most frequent gene aberrations in human cancer. Such alterations have been shown to have an impact on tumor microenvironnement and on the capacity of tumors to respond to immune-checkpoint inhibitors (ICI). We an...